Difficult wounds include all skin lesions, characterized by the absence or low speed of healing, resulting from chronic pathologies, infections, diabetes, immune diseases, trauma, amputations, post-operative complications, etc. These are serious diseases that can lead to amputation and which are widespread especially in the elderly population (prevalence 3% of the population over 65 years). Only in Italy it is estimated that there are 2 million individuals afflicted with these pathologies.

PREFER is a project which aims to create an Advanced Therapy Medicinal Product (ATMP) that is able to revascularize the tissues affected by such wounds, and by doing so, to heal them.